Louisville Leopards Vs. Lake Blue Streaks
Girls Lacrosse All-Time Series
Overall: 7-6 | Home: 4-2 | Away: 3-4
Total Goals: Louisville 112, Lake 94
Average Score: Louisville 9, Lake 7
| Game | Date | Location | W-L-T | Louisville | Lake |
| 1 | 4/2/2016 | Away | W | 16 | 3 |
| 2 | 4/28/2016 | Home | W | 13 | 5 |
| 3 | 4/10/2017 | Home | W | 17 | 2 |
| 4 | 4/17/2017 | Away | W | 9 | 5 |
| 5 | 3/22/2018 | Home | W | 12 | 1 |
| 6 | 4/14/2018 | Away | W | 16 | 2 |
| 7 | 4/1/2019 | Home | W | 10 | 9 |
| 8 | 5/2/2019 | Away | L | 6 | 10 |
| 9 | 3/22/2021 | Away | L | 4 | 7 |
| 10 | 4/26/2021 | Home | L | 4 | 14 |
| 11 | 5/15/2021 | Away | L | 2 | 15 |
| 12 | 5/5/2022 | Away | L | 2 | 9 |
| 13 | 4/10/2023 | Home | L | 1 | 12 |
Notable Louisville Vs. Lake Girls Lacrosse Games
- The 4/2/2016 game played at Lake was the first game in the history of the Louisville Leopards Girls Lacrosse Program.
- The 5/15/2021 was a Division II, Region 6 Opening Round Tournament Game.
