2025 Louisville Leopards Football Schedule
| Week | Date | Opponent | W-L | Louisville | Opponent | |
| 1 | 8/22 | at New Philadelphia | ||||
| 2 | 8/29 | at Alliance | ||||
| 3 | 9/5 | Northwest | ||||
| 4 | 9/12 | at Marlington | ||||
| 5 | 9/19 | North Canton Hoover | ||||
| 6 | 9/26 | at Canton Central Catholic | ||||
| 7 | 10/3 | Canfield | ||||
| 8 | 10/10 | at Green | ||||
| 9 | 10/17 | La Salle | ||||
| 10 | 10/24 | Wooster |
2024 Louisville Leopards Football Schedule
| Game | Date | Opponent | Time | Louisville | Opponent | |
| 1 | 8/23 | New Philadelphia | L | 7 | 12 | |
| 2 | 8/30 | Alliance | W | 40 | 14 | |
| 3 | 9/6 | at Northwest | L | 28 | 35 | |
| 4 | 9/13 | Marlington | W | 38 | 13 | |
| 5 | 9/20 | at North Canton Hoover | L | 16 | 23 | |
| 6 | 9/27 | Canton Central Catholic | W | 7 | 6 | |
| 7 | 10/4 | at Canfield | L | 16 | 23 | |
| 8 | 10/11 | Green | L | 0 | 28 | |
| 9 | 10/18 | South Range | L | 28 | 49 | |
| 10 | 10/25 | at Wooster | W | 20 | 17 |
