Louisville Leopards Varsity Football 2010 Season
- Head Coach: John Demarco (1st Year)
- Overall Record: 7-3
- NBC Record: 6-1 (2nd)
- Home 5-0, Away 2-3
2010 Louisville Leopards Football Schedule & Results
| Week | Date | Opponent | W-L | Louisville | Opponent |
| PRE-1 | at Canfield (Scrimmage) | ||||
| PRE-2 | at Orrville (Scrimmage | ||||
| 1 | 8/27 | at Walsh Jesuit | L | 14 | 28 |
| 2 | 9/3 | at Hoover | L | 25 | 28 |
| 3 | 9/10 | Ravenna | W | 37 | 34 |
| 4 | 9/17 | Canton South | W | 21 | 17 |
| 5 | 9/24 | at Northwest | W | 39 | 14 |
| 6 | 10/1 | West Branch | W | 28 | 0 |
| 7 | 10/8 | at Carrollton | W | 45 | 34 |
| 8 | 10/15 | Alliance | W | 44 | 14 |
| 9 | 10/22 | at Marlington | L | 7 | 21 |
| 10 | 10/29 | Minerva | W | 42 | 20 |
2010 NBC Football Standings
| Team | W | L | W | L |
| X-Marlington Dukes |
7 |
0 |
13 |
1 |
| Louisville Leopards |
6 |
1 |
7 |
3 |
| Minerva Lions |
5 |
2 |
8 |
3 |
| Alliance Aviators |
3 |
4 |
5 |
5 |
| Northwest Indians |
3 |
4 |
4 |
6 |
| Carrollton Warriors |
2 |
5 |
4 |
6 |
| Canton South Wildcats |
2 |
5 |
3 |
7 |
| West Branch Warriors |
0 |
7 |
1 |
9 |
| X-Outright NBC Champions |
