2025 Louisville Leopards Football Schedule
| Week | Date | Opponent | W-L | Louisville | Opponent |
| 1 | 8/22 | at New Philadelphia | W | 24 | 0 |
| 2 | 8/29 | at Alliance | W | 30 | 13 |
| 3 | 9/5 | Northwest | W | 10 | 3 |
| 4 | 9/12 | at Marlington | W | 45 | 7 |
| 5 | 9/19 | North Canton Hoover | L | 13 | 31 |
| 6 | 9/26 | at Canton Central Catholic | W | 21 | 0 |
| 7 | 10/3 | Canfield | L | 21 | 23 |
| 8 | 10/10 | at Green | L | 14 | 27 |
| 9 | 10/17 | La Salle | L | 24 | 35 |
| 10 | 10/24 | Wooster | W | 50 | 7 |
| DIII, REGION 7 PLAYOFFS | |||||
| 11 | 10/31 | at #5 Westerville South | L | 10 | 14 |
