Louisville Leopards Football 1959
- Head Coach: James Morgan (8th Year)
- Overall: 7-2-1
- Tri-County: 5-1-1
- Home 4-0-1, Away 3-2-0
- East Palestine Bulldogs Outright Tri-County League Champions
Louisville Leopards 1959 Football Schedule
| Week | Date | Opponent | W-L | Louisville | Opponent |
| 1 | 9/19 | at Glenwood | L | 0 | 18 |
| 2 | 9/25 | Leetonia | W | 44 | 8 |
| 3 | 10/2 | at Sebring | W | 48 | 6 |
| 4 | 10/9 | North Canton Hoover | W | 12 | 6 |
| 5 | 10/16 | Poland | W | 38 | 6 |
| 6 | 10/23 | at Lisbon | W | 22 | 8 |
| 7 | 10/29 | at Canton South | W | 20 | 14 |
| 8 | 11/6 | at East Palestine | L | 0 | 6 |
| 9 | 11/13 | Minerva | T | 0 | 0 |
| 10 | 11/20 | Columbiana | W | 32 | 0 |
1959 Tri-County League Football Standings
| Tri-County Standings | W | L | T |
| X-East Palestine Bulldogs | 6 | 1 | 0 |
| Louisville Leopards | 5 | 1 | 1 |
| Lisbon Blue Devils | 5 | 2 | 0 |
| Minerva Lions | 4 | 2 | 1 |
| Poland Bulldogs | 4 | 3 | 0 |
| Leetonia Bears | 2 | 5 | 0 |
| Columbiana Clippers | 1 | 6 | 0 |
| Sebring Trojans | 0 | 7 | 0 |
| X-Outright Tri-County League Champions | |||
1959 Louisville Leopards Football Roster
James Andrews, Robert Bardash, Gary Bardash, Dennis Biery, William Boyle, Larry Buckler, Warren Cain, Norman Calder, Gene Connor, Howard Daugherty, Maurice DeHoff, Jerry Dunbar, William Ehlers, Dwight Fickes, Will Fladung, Terry Hanlon, Thomas Hiner, Matthew Hunt, Larry Isgro, Thomas Kerstetter, Kenneth Kindler, Philip Koehler, Richard Krabill, Thomas Lemmon, Jay Linder, James McKimm, Garry Meese, Mark Michel, Larry Miller, Kenneth Monnot, Deaan Pugh, George Pumneo, Oliver Roberts, Roger Samblanet, Bernard Schmucker, John Shank, William Steadman, Fred Tuttle, Patrick Veigh
