Louisville Leopards Football 1990
- Head Coach: Rick Crislip (3rd Year)
- Overall Record: 7-3
- NBC: 5-2
- Home 4-1, Away 3-2
- West Branch Warriors Outright NBC Champions
- 1st Year in the Northeastern Buckeye Conference
1990 Louisville Leopards Football Schedule
| Week | Date | Opponent | W-L | Louisville | Opponent |
| 1 | 8/24 | at North Canton Hoover | L | 7 | 24 |
| 2 | 8/31 | Ravenna | W | 22 | 10 |
| 3 | 9/7 | at Wintersville | W | 16 | 7 |
| 4 | 9/14 | Marlington | W | 34 | 0 |
| 5 | 9/21 | at Carrollton | W | 48 | 6 |
| 6 | 9/28 | Canton South | W | 21 | 0 |
| 7 | 10/5 | at Dover | L | 21 | 28 |
| 8 | 10/12 | Northwest | W | 28 | 6 |
| 9 | 10/19 | West Branch | L | 15 | 35 |
| 10 | 10/26 | at Minerva | W | 36 | 16 |
