Louisville Leopards Football 1980
- Head Coach: Paul Starkey (16th Year)
- Overall Record: 6-3-1
- Federal League: 4-2-0
- Home 4-0-1, Away 2-3-0
- North Canton Hoover Vikings and Perry Panthers Co-Federal League Champions (5-1)
1980 Louisville Leopards Football Schedule
| Week | Date | Opponent | W-L | Louisville | Opponent |
| 1 | 8/29 | at Minerva | W | 42 | 0 |
| 2 | 9/5 | Perry | W | 10 | 7 |
| 3 | 9/12 | Jackson | W | 7 | 6 |
| 4 | 9/20 | at Canton McKinley | L | 14 | 29 |
| 5 | 9/26 | at Marlington | W | 20 | 8 |
| 6 | 10/3 | Canton Timken | W | 23 | 7 |
| 7 | 10/10 | Canton South | W | 31 | 8 |
| 8 | 10/17 | at GlenOak | L | 19 | 29 |
| 9 | 10/24 | at North Canton Hoover | L | 14 | 15 |
| 10 | 10/31 | Alliance | T | 19 | 19 |
Note: the season finally against Alliance was the last tie in Louisville Leopards Football history.
